DNA methylation in rat tissues by a series of homologous aliphatic nitrosamines ranging from N-nitrosodimethylamine to N-nitrosomethyldodecylamine
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چکیده
منابع مشابه
Study of DNA methylation by tobacco-specific N-nitrosamines.
An enzyme-linked immunosorbent assay (BA-ELISA) involving use of biotin-labeled anti-rabbit IgG and avidin-labeled horseradish peroxidase was developed for the measurement of O6-methyl-2'-deoxyguanosine (O6-MedGuo). Up to 5 micrograms of methylated DNA was enzymatically hydrolyzed, and the extent of inhibition of binding of immobilized O6-MedGuo-bovine serum albumin to rabbit anti-O6-MedGuo was...
متن کاملMetabolism of N-nitrosamines by cultured human and rat esophagus.
The metabolism of several N-nitrosamines (N-nitrosodimethylamine, N-nitrosoethylmethylamine, N-nitrosodiethylamine, N-nitrosobenzylmethylamine, and N-nitrosopyrrolidine) in cultured human and rat esophagus has been investigated by measuring (a) CO2, (b) metabolites with an oxo group, and (c) metabolites bound to DNA. Both acyclic and cyclic N-nitrosamines were metabolized by rat esophagus. The ...
متن کاملMetabolic denitrosation of N-nitrosodimethylamine in vivo in the rat.
Enzymatic denitrosation is a potentially inactivating metabolic route that has been shown to convert carcinogenic N-nitrosodimethylamine (NDMA) to methylamine (MA) in vitro. To investigate its quantitative course in vivo, groups of 8-week-old male Fischer rats have been given small (8-15 mumol/kg) p.o. or i.v. bolus doses of 14C-labeled NDMA and the subsequent formation of radioactive MA has be...
متن کاملfrom linguistics to literature: a linguistic approach to the study of linguistic deviations in the turkish divan of shahriar
chapter i provides an overview of structural linguistics and touches upon the saussurean dichotomies with the final goal of exploring their relevance to the stylistic studies of literature. to provide evidence for the singificance of the study, chapter ii deals with the controversial issue of linguistics and literature, and presents opposing views which, at the same time, have been central to t...
15 صفحه اولMETHYLA TION OF LIVER DNA OF RAT AND MOUSE BY N-NITROSODIMETHYLAMINE FORMED IN VIVO FROM OlMETHYLAMINE AND NITRITE*
--The extent of formation of N-nitrosodimethylaminc {NDMA) in the stomachs of rats and mice after sirnultancous oral administration of [ C]dimethylamine and potassiu.m nitrite ~as determined by measuring the methylation of liver DNA. With doses of around I mg d1m~thylamm~ hydrochloride/kg body weight and 50 mg potassium nitrite/kg body w~ight. OJ{'\, of the arnme was n:.tr~satcd . on average. T...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1987
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/8.9.1337